Spyre Therapeutics, Inc. (SYRE)

NasdaqGS · Biotechnology

107.27
-0.55 (-0.51%)
Updated Aug 19, 5:45 PM ET
AI Rating
Hold
Overall Score
61
Trend
75
Momentum
60
Risk
38

Scores are generated from technical indicators for educational purposes and are not a recommendation to buy or sell.

Price history

Daily closes and volume
Feb 24, 2026 120 sessions Aug 14, 2026

AI Analysis

Spyre Therapeutics, Inc. is trading at $107.27, down 0.51% on the session. The 50 day average sits at $93.76 and the 200 day at $n/a, which puts the stock in a mixed technical position. RSI is at 56.1, which reads as strong, and MACD is bearish crossover. Volume is below average.

The nearest support is around $92.71 with resistance near $105.05, so that band frames the current range. Average daily movement is roughly $5.93, or about 5.5% of the share price, which is what any stop placement has to allow for. The overall health score of 61 out of 100 combines a trend score of 75, momentum of 60 and a risk score of 38.

Technical indicators

RSI (14)
56.1
strong
MACD
2.829
bearish crossover
SMA 20
101.46
SMA 50
93.76
SMA 200
--
unknown
ATR (14)
5.93
avg daily range
Support
92.71
Resistance
105.05
Volume vs 20d
0.68x
below average
Volatility
53.8%
annualised
1 month
+10.10%
3 months
+36.99%

About Spyre Therapeutics, Inc.

Spyre Therapeutics, Inc., a clinical stage biotechnology company, focuses on developing therapeutics for patients living with inflammatory bowel disease (IBD) and rheumatic diseases. The company develops SPY001, a humanized monoclonal immunoglobulin G1 antibody that is in phase-2 clinical stage designed to bind selectively to the a4ß7 integrin being developed for the treatment of IBD (ulcerative colitis and Crohn's disease); and SPY002 and SPY072 – anti-TL1A mAbs designed to bind to tumor necrosis factor-like ligand 1A (TL1A). It is also developing SPY003, a clinical-stage program, which is in phase-2 clinical stage designed to bind to interleukin 23 (IL-23); SPY120, a combination of anti-a4ß7 and anti-TL1A mAbs; SPY130, a combination anti-a4ß7 and anti-IL-23 mAbs; and SPY230, a combination anti-TL1A and anti-IL-23 mAbs. The company was formerly known as Aeglea BioTherapeutics, Inc. and changed its name to Spyre Therapeutics, Inc. in November 2023. The company was incorporated in 2013 and is based in Waltham, Massachusetts.

Company website

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