Markets
Today's Top Losers
The largest daily percentage declines across the stocks we cover, updated through the session.
25 stocks
Wednesday, September 23, 2026| # | Symbol | Price | Change | Volume | Market Cap | AI Score | AI Rating |
|---|---|---|---|---|---|---|---|
| 1 |
|
16.87 | -4.80 (-22.15%) | 2.58M | 1.04B | 49 | Hold |
| 2 |
ALKT
Alkami Technology Inc
|
14.66 | -3.43 (-18.96%) | 7.73M | 1.56B | 48 | Hold |
| 3 |
RAPP
Rapport Therapeutics Inc
|
34.13 | -7.34 (-17.70%) | 742.82K | 1.64B | 44 | Hold |
| 4 |
|
31.39 | -6.14 (-16.36%) | 10.60M | 1.92B | 46 | Hold |
| 5 |
|
12.78 | -2.21 (-14.74%) | 198.08K | 7.47M | 40 | Sell |
| 6 |
|
10.03 | -1.48 (-12.86%) | 3.07M | 172.46M | 26 | Strong Sell |
| 7 |
|
33.31 | -4.86 (-12.73%) | 1.11M | 4.11B | 32 | Sell |
| 8 |
|
8.13 | -1.18 (-12.68%) | 2.04M | 416.38M | 29 | Sell |
| 9 |
JBIO
Jade Biosciences Inc
|
14.71 | -2.05 (-12.23%) | 1.46M | 935.52M | 35 | Sell |
| 10 |
|
1.45 | -0.20 (-12.12%) | 889.23K | 1.56M | 24 | Strong Sell |
| 11 |
VOR
Vor Biopharma Inc
|
19.37 | -2.63 (-11.96%) | 2.76M | 1.15B | 57 | Hold |
| 12 |
|
12.52 | -1.69 (-11.89%) | 2.01M | 719.10M | 52 | Hold |
| 13 |
|
9.26 | -1.25 (-11.89%) | 12.18M | 2.73B | 36 | Sell |
| 14 |
|
22.49 | -3.02 (-11.84%) | 858.03K | 936.28M | 31 | Sell |
| 15 |
EOSE
Eos Energy Enterprises Inc
|
3.58 | -0.48 (-11.82%) | 28.77M | 1.29B | 33 | Sell |
| 16 |
|
13.56 | -1.73 (-11.32%) | 1.42M | 1.77B | 30 | Sell |
| 17 |
|
18.52 | -2.31 (-11.09%) | 688.96K | 845.46M | 33 | Sell |
| 18 |
TRAX
First Tracks Biotherapeutics Inc
|
36.66 | -4.37 (-10.65%) | 647.29K | 1.31B | 30 | Sell |
| 19 |
|
27.51 | -3.27 (-10.62%) | 571.42K | 1.08B | 52 | Hold |
| 20 |
STOK
Stoke Therapeutics Inc
|
26.11 | -3.09 (-10.58%) | 1.13M | 1.68B | 26 | Strong Sell |
| 21 |
ZBIO
Zenas Biopharma Inc
|
29.63 | -3.42 (-10.35%) | 520.38K | 1.93B | 62 | Hold |
| 22 |
ERAS
Erasca Inc
|
13.95 | -1.61 (-10.32%) | 3.79M | 4.88B | 43 | Hold |
| 23 |
|
8.02 | -0.90 (-10.09%) | 1.08M | 859.95M | 55 | Hold |
| 24 |
BCAX
Bicara Therapeutics Inc
|
20.49 | -2.30 (-10.08%) | 953.15K | 1.36B | 44 | Hold |
| 25 |
PGY
Pagaya Technologies Ltd
|
18.72 | -2.05 (-9.87%) | 6.59M | 1.56B | 59 | Hold |
How to read this list
A large percentage move on its own says very little. What matters is whether volume supports the move, whether the stock is moving with its sector or against it, and where price now sits relative to its recent range. Open any symbol to see those readings, the AI health score behind it, and the levels that currently frame the trade.
Sub dollar names and stocks trading under 50,000 shares are excluded, because tiny volume produces percentage moves that cannot actually be traded.